Gordon S Mitchell

Gordon S Mitchell, Ph.D.

Professor

Department: HP-PHYSICAL THERAPY
Business Phone: (352) 273-6085
Business Email: gsmitche@phhp.ufl.edu

About Gordon S Mitchell

Dr. Mitchell joined the University of Florida in 2015 as a Preeminence Professor of Neuroscience in the Department of Physical Therapy and McKnight Brain Institute. He founded and directs the UF Center for Breathing Research and Therapeutics (BREATHE) and the NIH-funded graduate and postdoctoral training program of the same name. A major focus of BREATHE is to understand and treat impaired breathing and airway defense (swallowing/cough) caused by neuromuscular injury or disease. Dr. Mitchell also serves as Deputy Director of the UF McKnight Brain Institute. For the past three decades, Dr. Mitchell pioneered studies of neuroplasticity in the neural system controlling breathing. Areas of active investigation include: intracellular and intercellular mechanisms of long-lasting respiratory motor plasticity triggered by repeated exposure to brief episodes of low oxygen (intermittent hypoxia), the ability to harness that intermittent hypoxia-induced spinal plasticity to treat respiratory and non-respiratory paralysis following spinal injury and during motor neuron disease (ALS), cell-based strategies to treat breathing deficits, and the impact of systemic inflammation on breathing and its control. Investigations span intracellular, intercellular and physiological systems level mechanisms, and translation to humans with acquired or neurodegenerative neurological disorders (SCI and ALS). Dr. Mitchell grew up in California where he received his B.S. (Biological Sciences) and PhD (Developmental and Cell Biology) degrees from the University of California at Irvine. After two years of post-doctoral training at the Max Planck Institute for Experimental Medicine in Goettingen, Germany, he moved to the University of Wisconsin-Madison. After one year as a postdoc, Dr. Mitchell became an Assistant Professor in 1981, and then the ranks to become Professor and Chair of the Department of Comparative Biosciences (17 years) and director of the NIH funded Respiratory Neurobiology Training Program (14 years). He chose to leave the University of Wisconsin for the opportunity to join the University of Florida and create the BREATHE Center. Dr. Mitchell has been recognized for his research and teaching accomplishments, including a National Institutes of Health MERIT Award, the Norden Distinguished Teacher Award, the Pfizer Research Award on multiple occasions, the Steenbock Professorship for Behavioral and Neural Science, and distinguished lectureships from the Society for Neuroscience (SFN), American Physiological Society (APS), Association of Chairs of Departments of Physiology (ACDP), American Spinal Injury Association (ASIA), and the Oxford Conference for Modeling and the Control of Breathing.

Teaching Profile

Courses Taught
2019-2025
RSD7980 Research for Doctoral Dissertation
2017-2025
RSD7979 Advanced Research
2017-2021
PHT6168C Neurosci Phys Therapy
2016-2020,2022-2025
RSD6930 Special Topics in Rehabilitation Science
2020
RSD6940 Supervised Teaching
2019
EGN4912 Engineering Directed Independent Research
2018,2023-2025
GMS7980 Research for Doctoral Dissertation
2016-2017,2021-2022
RSD6910 Supervised Research
2016-2017
RSD6905 Individual Work
2015
GMS7794 Neuroscience Seminar
2015
PHT6935C Seminar
2021,2023-2024
RSD6920 Rehabilitation Science Journal Club
2021-2022
HSC4970 Public Health and Health Professions Senior Honors Thesis
2022-2023
GMS6905 Independent Studies in Medical Sciences
2022
GMS7979 Advanced Research
2023-2024
GMS6090 Research in Medical Sciences
2024-2025
GMS6971 Research for Master’s Thesis

Research Profile

Research interests: As one of the first to recognize the importance of neuroplasticity in the neural control of breathing, Dr. Mitchell has spent decades studying neuroplasticity in respiratory (and more recently non-respiratory) motor systems. His primary research interests concern intracellular and intercellular (neuron/microglial) mechanisms regulating spinal motor plasticity following acute intermittent hypoxia (AIH), and efforts to harness intermittent hypoxia-induced plasticity to treat devastating clinical disorders that compromise breathing, such as cervical spinal cord injury and ALS. His approach spans from cellular/molecular studies to integrative physiology and pathophysiology in rodent models to human clinical trials of injury/disease .

Funding and collaborations: Dr. Mitchell has maintained an active, extramurally funded research program with continuous NIH funding since 1983, including NHLBI Research Career Development and MERIT awards along the way. He is currently PI of 3 NHLBI-funded R01s that focus on: 1) (intra)cellular mechanisms of AIH-induced phrenic motor plasticity; 2) intercellular mechanisms whereby normal or inflamed microglia regulate phrenic motor plasticity; and 3) optimizing AIH protocols to maximize plasticity and therapeutic efficacy in rodent models of cervical SCI. Each grant feeds directly into ongoing clinical trials of AIH to restore breathing ability (and limb function) in people living with chronic SCI or ALS. He is also co-PI or co-investigator on additional grants from the NIH (R01, R21), Department of Defense and Craig H. Neilsen Foundation. Through these funded studies, he maintains collaborations with outstanding scientists that have expertise in respiratory physiology, cell/molecular neurobiology, rodent models of neural injury/disease, human physiology and clinical trials of therapeutic AIH. For example, in collaboration with Dr. Emily Fox, Director of Neuromuscular Research at Brooks Rehabilitation, he co-directs two DoD-funded clinical trials of combined AIH with respiratory strength training to rehabilitate breathing in people with chronic SCI. He also maintains collaborations concerning: 1) therapeutic AIH as a means of restoring breathing ability in human ALS (PI Barbara Smith)); and 2) walking ability (Dr. Randy Trumbower, Spaulding/Harvard, Boston) and 3) arm/hand function (Monica Perez, Milap Sandhu and W. Zev Rymer, Shirley Ryan Ability Lab, Chicago) in people with chronic SCI. Thus, his research program operates as a “translational flywheel”: basic science studies inform human clinical trials, which clarify the need for additional research.

Scholarly publications: Over the past 4 decades, Dr. Mitchell has published 313 manuscripts in major, peer-reviewed scientific journals and earned an H-index of 77 and an i10-index of 268 with over 20-thousand citations of his work; in the past 5 years.

Dr. Mitchell currently directs Breathing Research and Therapeutics (BREATHE) Training Program. He has mentored >30 postdoctoral trainees, supervised >30 graduate students, and served on >60 additional graduate thesis committees. He currently supervises 4 graduate students and 3 postdocs, while co-mentoring 3 other postdoctoral trainees. His trainees have been highly successful, with many winning awards from national or international organizations for research excellence. Over 30 former trainees are now faculty at academic institutions, many with extramurally funded research programs.

Recognition and service: Dr. Mitchell has contributed to the larger academic community through university, national and international service (eg. NIH study sections). With the onset of the Covid-19 pandemic, he founded the International Online Seminar Series on the Control of Breathing and Airway Defense (CoBAD). He also founded the Neurotherapeutic AIH Consortium in 2016, an international group aiming to translate therapeutic AIH to a phase III clinical trial. Under his direction, the UF BREATHE Center organized consortium workshops in 2016, 2018, 2020, and 2022 focused on advancing “A roadmap to clinical translation: therapeutic intermittent hypoxia and recovery of motor function with chronic, incomplete SCI”.

Open Researcher and Contributor ID (ORCID)

0000-0002-8489-1861

Areas of Interest
  • ALS
  • Intermittent hypoxia
  • Neuroplasticity
  • Respiratory physiology
  • Sleep apnea
  • Spinal cord injury rehabilitation

Publications

2024
Cardiorespiratory Responses to Acute Intermittent Hypoxia in Humans With Chronic Spinal Cord Injury.
Journal of neurotrauma. [DOI] 10.1089/neu.2023.0353. [PMID] 38468543.
2024
Inactivity-induced phrenic motor facilitation requires PKCζ activity within phrenic motor neurons
Journal of Neurophysiology. 131(6):1188-1199 [DOI] 10.1152/jn.00138.2024.
2024
Inaugural Review Prize 2023: The exercise hyperpnoea dilemma: A 21st-century perspective.
Experimental physiology. [DOI] 10.1113/EP091506. [PMID] 38551996.
2024
Microglia regulate motor neuron plasticity via reciprocal fractalkine/adenosine signaling.
bioRxiv : the preprint server for biology. [DOI] 10.1101/2024.05.07.592939. [PMID] 38765982.
2024
Prolonged intermittent hypoxia differentially regulates phrenic motor neuron serotonin receptor expression in rats following chronic cervical spinal cord injury.
Experimental neurology. 378 [DOI] 10.1016/j.expneurol.2024.114808. [PMID] 38750949.
2023
A Research Protocol to Study the Priming Effects of Breathing Low Oxygen on Enhancing Training-Related Gains in Walking Function for Persons With Spinal Cord Injury: The BO2ST Trial.
Neurotrauma reports. 4(1):736-750 [DOI] 10.1089/neur.2023.0036. [PMID] 38028272.
2023
APOE4, Age & Sex Regulate Respiratory Plasticity Elicited By Acute Intermittent Hypercapnic-Hypoxia.
bioRxiv : the preprint server for biology. [DOI] 10.1101/2023.01.06.522840. [PMID] 36711653.
2023
APOE4, Age, and Sex Regulate Respiratory Plasticity Elicited by Acute Intermittent Hypercapnic-Hypoxia.
Function (Oxford, England). 4(5) [DOI] 10.1093/function/zqad026. [PMID] 37575478.
2023
BDNF-induced phrenic motor facilitation shifts from PKCθ to ERK dependence with mild systemic inflammation
Journal of Neurophysiology. 129(2):455-464 [DOI] 10.1152/jn.00345.2022. [PMID] 36695529.
2023
Cervical spinal hemisection effects on spinal tissue oxygenation and long-term facilitation of phrenic, renal and splanchnic sympathetic nerve activity.
Experimental neurology. 368 [DOI] 10.1016/j.expneurol.2023.114478. [PMID] 37451584.
2023
Increased spinal adenosine impairs phrenic long-term facilitation in aging rats
Journal of Applied Physiology. 134(6):1537-1548 [DOI] 10.1152/japplphysiol.00197.2023. [PMID] 37167263.
2023
Magnitude and Mechanism of Phrenic Long-term Facilitation Shift Between Daily Rest Versus Active Phase.
Function (Oxford, England). 4(6) [DOI] 10.1093/function/zqad041. [PMID] 37753182.
2023
Mild inflammation impairs acute intermittent hypoxia-induced phrenic long-term facilitation by a spinal adenosine-dependent mechanism
Journal of Neurophysiology. 129(4):799-806 [DOI] 10.1152/jn.00035.2023. [PMID] 36883762.
2023
Progressive tauopathy disrupts breathing stability and chemoreflexes during presumptive sleep in mice.
Frontiers in physiology. 14 [DOI] 10.3389/fphys.2023.1272980. [PMID] 37811498.
2022
Acute intermittent hypercapnic‐hypoxia elicits central neural respiratory motor plasticity in humans
The Journal of Physiology. 600(10):2515-2533 [DOI] 10.1113/jp282822.
2022
Acute intermittent hypoxia and respiratory muscle recruitment in people with amyotrophic lateral sclerosis: A preliminary study.
Experimental neurology. 347 [DOI] 10.1016/j.expneurol.2021.113890. [PMID] 34624328.
2022
Caffeine Enhances Intermittent Hypoxia-Induced Gains in Walking Function for People with Chronic Spinal Cord Injury.
Journal of neurotrauma. 39(23-24):1756-1763 [DOI] 10.1089/neu.2022.0120. [PMID] 35686460.
2022
Daily acute intermittent hypoxia enhances serotonergic innervation of hypoglossal motor nuclei in rats with and without cervical spinal injury.
Experimental neurology. 347 [DOI] 10.1016/j.expneurol.2021.113903. [PMID] 34699788.
2022
Dose-dependent phosphorylation of endogenous Tau by intermittent hypoxia in rat brain
Journal of Applied Physiology. 133(3):561-571 [DOI] 10.1152/japplphysiol.00332.2022. [PMID] 35861520.
2022
Intermittent Hypoxia Differentially Regulates Adenosine Receptors in Phrenic Motor Neurons with Spinal Cord Injury.
Neuroscience. 506:38-50 [DOI] 10.1016/j.neuroscience.2022.10.007. [PMID] 36273657.
2022
Respiratory neuroplasticity: Mechanisms and translational implications of phrenic motor plasticity.
Handbook of clinical neurology. 188:409-432 [DOI] 10.1016/B978-0-323-91534-2.00016-3. [PMID] 35965036.
2022
Therapeutic acute intermittent hypoxia: A translational roadmap for spinal cord injury and neuromuscular disease.
Experimental neurology. 347 [DOI] 10.1016/j.expneurol.2021.113891. [PMID] 34637802.
2021
Acute intermittent hypoxia boosts spinal plasticity in humans with tetraplegia.
Experimental neurology. 335 [DOI] 10.1016/j.expneurol.2020.113483. [PMID] 32987000.
2021
Acute morphine blocks spinal respiratory motor plasticity via long‐latency mechanisms that require toll‐like receptor 4 signalling
The Journal of Physiology. 599(15):3771-3797 [DOI] 10.1113/jp281362.
2021
Baseline Arterial CO2 Pressure Regulates Acute Intermittent Hypoxia-Induced Phrenic Long-Term Facilitation in Rats.
Frontiers in physiology. 12 [DOI] 10.3389/fphys.2021.573385. [PMID] 33716760.
2021
Cervical spinal injury compromises caudal spinal tissue oxygenation and undermines acute intermittent hypoxia-induced phrenic long-term facilitation.
Experimental neurology. 342 [DOI] 10.1016/j.expneurol.2021.113726. [PMID] 33915165.
2021
Crossing the blood-brain barrier with carbon dots: uptake mechanism and in vivo cargo delivery.
Nanoscale advances. 3(13):3942-3953 [DOI] 10.1039/d1na00145k. [PMID] 34263140.
2021
Daily acute intermittent hypoxia enhances phrenic motor output and stimulus-evoked phrenic responses in rats.
Journal of neurophysiology. 126(3):777-790 [DOI] 10.1152/jn.00112.2021. [PMID] 34260289.
2021
Effect of acute intermittent hypoxia on cortico-diaphragmatic conduction in healthy humans.
Experimental neurology. 339 [DOI] 10.1016/j.expneurol.2021.113651. [PMID] 33607080.
2021
Efficacy and time course of acute intermittent hypoxia effects in the upper extremities of people with cervical spinal cord injury.
Experimental neurology. 342 [DOI] 10.1016/j.expneurol.2021.113722. [PMID] 33932397.
2021
Phrenic motor neuron survival below cervical spinal cord hemisection.
Experimental neurology. 346 [DOI] 10.1016/j.expneurol.2021.113832. [PMID] 34363808.
2021
Prolonged acute intermittent hypoxia improves forelimb reach-to-grasp function in a rat model of chronic cervical spinal cord injury.
Experimental neurology. 340 [DOI] 10.1016/j.expneurol.2021.113672. [PMID] 33652030.
2021
Protocol-Specific Effects of Intermittent Hypoxia Pre-Conditioning on Phrenic Motor Plasticity in Rats with Chronic Cervical Spinal Cord Injury.
Journal of neurotrauma. 38(9):1292-1305 [DOI] 10.1089/neu.2020.7324. [PMID] 33446048.
2021
Serotonergic innervation of respiratory motor nuclei after cervical spinal injury: Impact of intermittent hypoxia.
Experimental neurology. 338 [DOI] 10.1016/j.expneurol.2021.113609. [PMID] 33460645.
2021
Silent hypoxaemia in COVID-19 patients.
The Journal of physiology. 599(4):1057-1065 [DOI] 10.1113/JP280769. [PMID] 33347610.
2021
Single-session effects of acute intermittent hypoxia on breathing function after human spinal cord injury.
Experimental neurology. 342 [DOI] 10.1016/j.expneurol.2021.113735. [PMID] 33951477.
2021
Systemic inflammation suppresses spinal respiratory motor plasticity via mechanisms that require serine/threonine protein phosphatase activity.
Journal of neuroinflammation. 18(1) [DOI] 10.1186/s12974-021-02074-6. [PMID] 33468163.
2021
The influence of intermittent hypoxia, obesity, and diabetes on male genitourinary anatomy and voiding physiology.
American journal of physiology. Renal physiology. 321(1):F82-F92 [DOI] 10.1152/ajprenal.00112.2021. [PMID] 34121451.
2020
Adenosine 2A receptor inhibition protects phrenic motor neurons from cell death induced by protein synthesis inhibition.
Experimental neurology. 323 [DOI] 10.1016/j.expneurol.2019.113067. [PMID] 31629857.
2020
Circadian clock genes and respiratory neuroplasticity genes oscillate in the phrenic motor system.
American journal of physiology. Regulatory, integrative and comparative physiology. 318(6):R1058-R1067 [DOI] 10.1152/ajpregu.00010.2020. [PMID] 32348679.
2020
Editorial: Neuromodulatory Control of Brainstem Function in Health and Disease.
Frontiers in neuroscience. 14 [DOI] 10.3389/fnins.2020.00086. [PMID] 32116528.
2020
Hypoxia-induced hypotension elicits adenosine-dependent phrenic long-term facilitation after carotid denervation.
Experimental neurology. 333 [DOI] 10.1016/j.expneurol.2020.113429. [PMID] 32735873.
2020
Mild to Moderate Sleep Apnea Is Linked to Hypoxia-induced Motor Recovery after Spinal Cord Injury.
American journal of respiratory and critical care medicine. 202(6):887-890 [DOI] 10.1164/rccm.202002-0245LE. [PMID] 32369393.
2020
Reliability of diaphragmatic motor-evoked potentials induced by transcranial magnetic stimulation.
Journal of applied physiology (Bethesda, Md. : 1985). 129(6):1393-1404 [DOI] 10.1152/japplphysiol.00486.2020. [PMID] 33031020.
2020
Spinal AMP kinase activity differentially regulates phrenic motor plasticity.
Journal of applied physiology (Bethesda, Md. : 1985). 128(3):523-533 [DOI] 10.1152/japplphysiol.00546.2019. [PMID] 31971473.
2020
Synergy between Acute Intermittent Hypoxia and Task-Specific Training.
Exercise and sport sciences reviews. 48(3):125-132 [DOI] 10.1249/JES.0000000000000222. [PMID] 32412926.
2019
Cancer cachexia impairs neural respiratory drive in hypoxia but not hypercapnia.
Journal of cachexia, sarcopenia and muscle. 10(1):63-72 [DOI] 10.1002/jcsm.12348. [PMID] 30362273.
2019
Cervical spinal 5-HT2A and 5-HT2B receptors are both necessary for moderate acute intermittent hypoxia-induced phrenic long-term facilitation.
Journal of applied physiology (Bethesda, Md. : 1985). 127(2):432-443 [DOI] 10.1152/japplphysiol.01113.2018. [PMID] 31219768.
2019
Cervical spinal contusion alters Na+-K+-2Cl- and K+-Cl- cation-chloride cotransporter expression in phrenic motor neurons.
Respiratory physiology & neurobiology. 261:15-23 [DOI] 10.1016/j.resp.2018.12.009. [PMID] 30590202.
2019
Circulatory control of phrenic motor plasticity
Respiratory Physiology & Neurobiology. 265:19-23 [DOI] 10.1016/j.resp.2019.01.004. [PMID] 30639504.
2019
Mechanisms of compensatory plasticity for respiratory motor neuron death.
Respiratory physiology & neurobiology. 265:32-39 [DOI] 10.1016/j.resp.2019.01.001. [PMID] 30625378.
2019
Prednisolone Pretreatment Enhances Intermittent Hypoxia-Induced Plasticity in Persons With Chronic Incomplete Spinal Cord Injury.
Neurorehabilitation and neural repair. 33(11):911-921 [DOI] 10.1177/1545968319872992. [PMID] 31524075.
2019
Protein kinase Cδ constrains the S‐pathway to phrenic motor facilitation elicited by spinal 5‐HT7 receptors or severe acute intermittent hypoxia
The Journal of Physiology. 597(2):481-498 [DOI] 10.1113/jp276731.
2018
Acute intermittent hypoxia enhances corticospinal synaptic plasticity in humans.
eLife. 7 [DOI] 10.7554/eLife.34304. [PMID] 29688171.
2018
Compensatory plasticity in diaphragm and intercostal muscle utilization in a rat model of ALS.
Experimental neurology. 299(Pt A):148-156 [DOI] 10.1016/j.expneurol.2017.10.015. [PMID] 29056361.
2018
Cross-talk inhibition between 5-HT2B and 5-HT7 receptors in phrenic motor facilitation via NADPH oxidase and PKA.
American journal of physiology. Regulatory, integrative and comparative physiology. 314(5):R709-R715 [DOI] 10.1152/ajpregu.00393.2017. [PMID] 29384698.
2018
Cyclooxygenase enzyme activity does not impair respiratory motor plasticity after one night of intermittent hypoxia.
Respiratory physiology & neurobiology. 256:21-28 [DOI] 10.1016/j.resp.2017.12.004. [PMID] 29233741.
2018
Intermittent but not sustained moderate hypoxia elicits long-term facilitation of hypoglossal motor output.
Respiratory physiology & neurobiology. 256:15-20 [DOI] 10.1016/j.resp.2017.10.005. [PMID] 29074449.
2018
Pharmacological modulation of hypoxia-induced respiratory neuroplasticity.
Respiratory physiology & neurobiology. 256:4-14 [DOI] 10.1016/j.resp.2017.11.008. [PMID] 29197629.
2018
Phrenic motor neuron adenosine 2A receptors elicit phrenic motor facilitation
The Journal of Physiology. 596(8):1501-1512 [DOI] 10.1113/jp275462.
2018
Spinal activation of protein kinase C elicits phrenic motor facilitation.
Respiratory physiology & neurobiology. 256:36-42 [DOI] 10.1016/j.resp.2017.10.007. [PMID] 29081358.
2018
Spinal protein phosphatase 1 constrains respiratory plasticity after sustained hypoxia.
Journal of applied physiology (Bethesda, Md. : 1985). 125(5):1440-1446 [DOI] 10.1152/japplphysiol.00641.2018. [PMID] 30161006.
2018
Systemic inflammation inhibits serotonin receptor 2-induced phrenic motor facilitation upstream from BDNF/TrkB signaling.
Journal of neurophysiology. 119(6):2176-2185 [DOI] 10.1152/jn.00378.2017. [PMID] 29513151.
2017
Adenosine-dependent phrenic motor facilitation is inflammation resistant.
Journal of neurophysiology. 117(2):836-845 [DOI] 10.1152/jn.00619.2016. [PMID] 27927784.
2017
Effect of acute intermittent hypoxia on motor function in individuals with chronic spinal cord injury following ibuprofen pretreatment: A pilot study.
The journal of spinal cord medicine. 40(3):295-303 [DOI] 10.1080/10790268.2016.1142137. [PMID] 26856344.
2017
Effects of acute intermittent hypoxia on hand use after spinal cord trauma: A preliminary study.
Neurology. 89(18):1904-1907 [DOI] 10.1212/WNL.0000000000004596. [PMID] 28972191.
2017
Mechanisms of Enhanced Phrenic Long-Term Facilitation in SOD1G93A Rats
The Journal of Neuroscience. 37(24):5834-5845 [DOI] 10.1523/jneurosci.3680-16.2017.
2017
Phrenic motor neuron TrkB expression is necessary for acute intermittent hypoxia-induced phrenic long-term facilitation.
Experimental neurology. 287(Pt 2):130-136 [DOI] 10.1016/j.expneurol.2016.05.012. [PMID] 27185271.
2017
Respiratory neuroplasticity – Overview, significance and future directions.
Experimental neurology. 287(Pt 2):144-152 [DOI] 10.1016/j.expneurol.2016.05.022. [PMID] 27208699.
2017
Short-term modulation of the ventilatory response to exercise is preserved in obstructive sleep apnea.
Respiratory physiology & neurobiology. 236:42-50 [DOI] 10.1016/j.resp.2016.11.003. [PMID] 27840272.
2017
Special Issue: Respiratory Neuroplasticity.
Experimental neurology. 287(Pt 2):91-92 [DOI] 10.1016/j.expneurol.2016.11.004. [PMID] 27871363.
2017
Spinal BDNF-induced phrenic motor facilitation requires PKCθ activity.
Journal of neurophysiology. 118(5):2755-2762 [DOI] 10.1152/jn.00945.2016. [PMID] 28855298.
2016
Mechanisms of microglial activation in models of inflammation and hypoxia: Implications for chronic intermittent hypoxia.
The Journal of physiology. 594(6):1563-77 [DOI] 10.1113/JP271502. [PMID] 26890698.
2016
Quantitative assessment of integrated phrenic nerve activity.
Respiratory physiology & neurobiology. 226:81-6 [DOI] 10.1016/j.resp.2015.12.005. [PMID] 26724605.
2016
Sustained Hypoxia Elicits Competing Spinal Mechanisms of Phrenic Motor Facilitation
The Journal of Neuroscience. 36(30):7877-7885 [DOI] 10.1523/jneurosci.4122-15.2016.
2015
Daily Acute Intermittent Hypoxia Elicits Functional Recovery of Diaphragm and Inspiratory Intercostal Muscle Activity After Acute Cervical Spinal Injury
Experimental Neurology. 266:1-10 [DOI] 10.1016/j.expneurol.2015.02.007. [PMID] 25687551.
2015
Intermittent hypoxia and neurorehabilitation.
Journal of applied physiology (Bethesda, Md. : 1985). 119(12):1455-65 [DOI] 10.1152/japplphysiol.00235.2015. [PMID] 25997947.
2015
Intermittent Hypoxia-Induced Spinal Inflammation Impairs Respiratory Motor Plasticity by a Spinal p38 MAP Kinase-Dependent Mechanism.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 35(17):6871-80 [DOI] 10.1523/JNEUROSCI.4539-14.2015. [PMID] 25926462.
2015
Mammalian target of rapamycin is required for phrenic long-term facilitation following severe but not moderate acute intermittent hypoxia.
Journal of neurophysiology. 114(3):1784-91 [DOI] 10.1152/jn.00539.2015. [PMID] 26224775.
2015
Phrenic Long-Term Facilitation Requires PKCθ Activity within Phrenic Motor Neurons
The Journal of Neuroscience. 35(21):8107-8117 [DOI] 10.1523/jneurosci.5086-14.2015.
2014
Adenosine 2A receptor inhibition enhances intermittent hypoxia-induced diaphragm but not intercostal long-term facilitation.
Journal of neurotrauma. 31(24):1975-84 [DOI] 10.1089/neu.2014.3393. [PMID] 25003645.
2014
Daily intermittent hypoxia enhances walking after chronic spinal cord injury: a randomized trial.
Neurology. 82(2):104-13 [DOI] 10.1212/01.WNL.0000437416.34298.43. [PMID] 24285617.
2014
Exercise training effects on hypoxic and hypercapnic ventilatory responses in mice selected for increased voluntary wheel running.
Experimental physiology. 99(2):403-13 [DOI] 10.1113/expphysiol.2013.076018. [PMID] 24142456.
2014
Spinal but not cortical microglia acquire an atypical phenotype with high VEGF, galectin-3 and osteopontin, and blunted inflammatory responses in ALS rats.
Neurobiology of disease. 69:43-53 [DOI] 10.1016/j.nbd.2013.11.009. [PMID] 24269728.
2014
Therapeutic potential of intermittent hypoxia: a matter of dose.
American journal of physiology. Regulatory, integrative and comparative physiology. 307(10):R1181-97 [DOI] 10.1152/ajpregu.00208.2014. [PMID] 25231353.
2013
Clinical challenges to ventilatory control.
Respiratory physiology & neurobiology. 189(2):211-2 [DOI] 10.1016/j.resp.2013.09.006. [PMID] 24056024.
2013
Common mechanisms of compensatory respiratory plasticity in spinal neurological disorders.
Respiratory physiology & neurobiology. 189(2):419-28 [DOI] 10.1016/j.resp.2013.05.025. [PMID] 23727226.
2013
Hypoxia Attenuates Purinergic P2X Receptor-Induced Inflammatory Gene Expression in Brainstem Microglia.
Hypoxia (Auckland, N.Z.). 2013(1):1-11 [DOI] 10.2147/HP.S45529. [PMID] 24377098.
2013
Hypoxia-induced phrenic long-term facilitation: emergent properties.
Annals of the New York Academy of Sciences. 1279:143-53 [DOI] 10.1111/nyas.12085. [PMID] 23531012.
2013
Intermittent hypoxia and stem cell implants preserve breathing capacity in a rodent model of amyotrophic lateral sclerosis.
American journal of respiratory and critical care medicine. 187(5):535-42 [DOI] 10.1164/rccm.201206-1072OC. [PMID] 23220913.
2013
Spinal vascular endothelial growth factor (VEGF) and erythropoietin (EPO) induced phrenic motor facilitation after repetitive acute intermittent hypoxia.
Respiratory physiology & neurobiology. 185(3):481-8 [DOI] 10.1016/j.resp.2012.10.014. [PMID] 23128070.
2012
7,8-dihydroxyflavone exhibits therapeutic efficacy in a mouse model of Rett syndrome.
Journal of applied physiology (Bethesda, Md. : 1985). 112(5):704-10 [DOI] 10.1152/japplphysiol.01361.2011. [PMID] 22194327.
2012
Cervical spinal erythropoietin induces phrenic motor facilitation via extracellular signal-regulated protein kinase and Akt signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(17):5973-83 [DOI] 10.1523/JNEUROSCI.3873-11.2012. [PMID] 22539857.
2012
Exposure to acute intermittent hypoxia augments somatic motor function in humans with incomplete spinal cord injury.
Neurorehabilitation and neural repair. 26(2):163-72 [DOI] 10.1177/1545968311412055. [PMID] 21821826.
2012
Glial activation in the spinal ventral horn caudal to cervical injury.
Respiratory physiology & neurobiology. 180(1):61-8 [DOI] 10.1016/j.resp.2011.10.011. [PMID] 22041654.
2012
Increased GABA(A) receptor ε-subunit expression on ventral respiratory column neurons protects breathing during pregnancy.
PloS one. 7(1) [DOI] 10.1371/journal.pone.0030608. [PMID] 22303446.
2012
Repetitive acute intermittent hypoxia increases expression of proteins associated with plasticity in the phrenic motor nucleus.
Experimental neurology. 237(1):103-15 [DOI] 10.1016/j.expneurol.2012.05.020. [PMID] 22704858.
2012
Repetitive intermittent hypoxia induces respiratory and somatic motor recovery after chronic cervical spinal injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(11):3591-600 [DOI] 10.1523/JNEUROSCI.2908-11.2012. [PMID] 22423083.
2012
Severe acute intermittent hypoxia elicits phrenic long-term facilitation by a novel adenosine-dependent mechanism.
Journal of applied physiology (Bethesda, Md. : 1985). 112(10):1678-88 [DOI] 10.1152/japplphysiol.00060.2012. [PMID] 22403346.
2011
Lipopolysaccharide attenuates phrenic long-term facilitation following acute intermittent hypoxia.
Respiratory physiology & neurobiology. 176(3):130-5 [DOI] 10.1016/j.resp.2011.02.008. [PMID] 21334467.
2011
Reduced respiratory neural activity elicits phrenic motor facilitation.
Respiratory physiology & neurobiology. 175(3):303-9 [DOI] 10.1016/j.resp.2010.12.005. [PMID] 21167322.
2011
Short-term modulation of the exercise ventilatory response in younger and older women.
Respiratory physiology & neurobiology. 179(2-3):235-47 [DOI] 10.1016/j.resp.2011.08.011. [PMID] 21890003.
2011
Should we standardize protocols and preparations used to study respiratory plasticity?
Respiratory physiology & neurobiology. 177(2):93-7 [DOI] 10.1016/j.resp.2011.03.021. [PMID] 21470581.
2011
Spinal vascular endothelial growth factor induces phrenic motor facilitation via extracellular signal-regulated kinase and Akt signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 31(21):7682-90 [DOI] 10.1523/JNEUROSCI.0239-11.2011. [PMID] 21613481.
2010
Multiple pathways to long-lasting phrenic motor facilitation.
Advances in experimental medicine and biology. 669:225-30 [DOI] 10.1007/978-1-4419-5692-7_45. [PMID] 20217354.
2010
Short- and long-term modulation of the exercise ventilatory response.
Medicine and science in sports and exercise. 42(9):1681-7 [DOI] 10.1249/MSS.0b013e3181d7b212. [PMID] 20164813.
2010
Short-term modulation of the exercise ventilatory response in older men.
Respiratory physiology & neurobiology. 173(1):37-46 [DOI] 10.1016/j.resp.2010.06.003. [PMID] 20601211.
2010
Spinal plasticity following intermittent hypoxia: implications for spinal injury.
Annals of the New York Academy of Sciences. 1198:252-9 [DOI] 10.1111/j.1749-6632.2010.05499.x. [PMID] 20536940.
2009
Breathing mechanics during exercise with added dead space reflect mechanisms of ventilatory control.
Respiratory physiology & neurobiology. 168(3):210-7 [DOI] 10.1016/j.resp.2009.07.001. [PMID] 19596464.
2009
Daily intermittent hypoxia augments spinal BDNF levels, ERK phosphorylation and respiratory long-term facilitation.
Experimental neurology. 217(1):116-23 [DOI] 10.1016/j.expneurol.2009.01.017. [PMID] 19416672.
2009
Developmental aspects of the upper airway: report from an NHLBI Workshop, March 5-6, 2009.
Proceedings of the American Thoracic Society. 6(6):513-20 [DOI] 10.1513/pats.200905-024CB. [PMID] 19741259.
2009
Intermittent hypoxia induces functional recovery following cervical spinal injury.
Respiratory physiology & neurobiology. 169(2):210-7 [DOI] 10.1016/j.resp.2009.07.023. [PMID] 19651247.
2008
Determinants of frequency long-term facilitation following acute intermittent hypoxia in vagotomized rats.
Respiratory physiology & neurobiology. 162(1):8-17 [DOI] 10.1016/j.resp.2008.03.005. [PMID] 18450525.
2008
Long-term effects of the perinatal environment on respiratory control.
Journal of applied physiology (Bethesda, Md. : 1985). 104(4):1220-9 [DOI] 10.1152/japplphysiol.01086.2007. [PMID] 18187608.
2008
Okadaic acid-sensitive protein phosphatases constrain phrenic long-term facilitation after sustained hypoxia.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 28(11):2949-58 [DOI] 10.1523/JNEUROSCI.5539-07.2008. [PMID] 18337426.
2008
Overview: the neurochemistry of respiratory control.
Respiratory physiology & neurobiology. 164(1-2):1-2 [DOI] 10.1016/j.resp.2008.07.021. [PMID] 18721910.
2008
Respiratory long-term facilitation: too much or too little of a good thing?
Advances in experimental medicine and biology. 605:224-7 [PMID] 18085276.
2008
Respiratory plasticity after perinatal hyperoxia is not prevented by antioxidant supplementation.
Respiratory physiology & neurobiology. 160(3):301-12 [PMID] 18069076.
2008
Short-term modulation of the exercise ventilatory response in young men.
Journal of applied physiology (Bethesda, Md. : 1985). 104(1):244-52 [PMID] 17991790.
2008
Simulated apnoeas induce serotonin-dependent respiratory long-term facilitation in rats.
The Journal of physiology. 586(8):2171-81 [DOI] 10.1113/jphysiol.2007.149047. [PMID] 18292130.
2008
Spinal adenosine A2a receptor activation elicits long-lasting phrenic motor facilitation.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 28(9):2033-42 [DOI] 10.1523/JNEUROSCI.3570-07.2008. [PMID] 18305238.
2007
Episodic stimulation of alpha1-adrenoreceptors induces protein kinase C-dependent persistent changes in motoneuronal excitability.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 27(16):4435-42 [PMID] 17442828.
2007
Is there a link between intermittent hypoxia-induced respiratory plasticity and obstructive sleep apnoea?
Experimental physiology. 92(1):27-37 [PMID] 17099064.
2006
Carotid sinus nerve responses and ventilatory acclimatization to hypoxia in adult rats following 2 weeks of postnatal hyperoxia.
Respiratory physiology & neurobiology. 150(2-3):155-64 [PMID] 15978876.
2006
Early postnatal chronic intermittent hypoxia modifies hypoxic respiratory responses and long-term phrenic facilitation in adult rats.
American journal of physiology. Regulatory, integrative and comparative physiology. 290(6):R1664-71 [PMID] 16455761.
2006
Layers of exercise hyperpnea: modulation and plasticity.
Respiratory physiology & neurobiology. 151(2-3):251-66 [PMID] 16530024.
2006
Recovery of phrenic activity and ventilation after cervical spinal hemisection in rats.
Journal of applied physiology (Bethesda, Md. : 1985). 100(3):800-6 [PMID] 16269524.
2006
Respiratory plasticity after perinatal hypercapnia in rats.
Respiratory physiology & neurobiology. 153(1):78-91 [PMID] 16338177.
2005
Carotid chemoafferent plasticity in adult rats following developmental hyperoxia.
Respiratory physiology & neurobiology. 145(1):3-11 [PMID] 15652783.
2005
Cervical spinal cord injury upregulates ventral spinal 5-HT2A receptors.
Journal of neurotrauma. 22(2):203-13 [PMID] 15716627.
2005
Differences in time-dependent hypoxic phrenic responses among inbred rat strains.
Journal of applied physiology (Bethesda, Md. : 1985). 98(3):838-44 [PMID] 15531560.
2005
Spinal synaptic enhancement with acute intermittent hypoxia improves respiratory function after chronic cervical spinal cord injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 25(11):2925-32 [PMID] 15772352.
2004
Back to the future: carbon dioxide chemoreceptors in the mammalian brain.
Nature neuroscience. 7(12):1288-90 [PMID] 15643436.
2004
BDNF is necessary and sufficient for spinal respiratory plasticity following intermittent hypoxia.
Nature neuroscience. 7(1):48-55 [PMID] 14699417.
2004
Breathing in thin air: acclimatization to altitude in ducks.
Respiratory physiology & neurobiology. 144(2-3):225-35 [PMID] 15556105.
2004
Concept mapping in pulmonary physiology using pathfinder scaling.
Advances in health sciences education : theory and practice. 9(3):225-40 [PMID] 15316273.
2003
Breathing: rhythmicity, plasticity, chemosensitivity.
Annual review of neuroscience. 26:239-66 [PMID] 12598679.
2003
Exercise increases hippocampal neurogenesis to high levels but does not improve spatial learning in mice bred for increased voluntary wheel running.
Behavioral neuroscience. 117(5):1006-16 [PMID] 14570550.
2003
Exercise-induced changes in hippocampal brain-derived neurotrophic factor and neurotrophin-3: effects of rat strain.
Brain research. 983(1-2):108-14 [PMID] 12914971.
2003
Intermittent hypoxia induces phrenic long-term facilitation in carotid-denervated rats.
Journal of applied physiology (Bethesda, Md. : 1985). 94(1):399-409 [PMID] 12391138.
2003
Neuroplasticity in respiratory motor control.
Journal of applied physiology (Bethesda, Md. : 1985). 94(1):358-74 [PMID] 12486024.
2003
Sex steroid hormones and the neural control of breathing.
Respiratory physiology & neurobiology. 136(2-3):249-63 [PMID] 12853015.
2003
Synaptic pathways to phrenic motoneurons are enhanced by chronic intermittent hypoxia after cervical spinal cord injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 23(7):2993-3000 [PMID] 12684486.
2002
Activity-dependent plasticity in descending synaptic inputs to respiratory spinal motoneurons.
Respiratory physiology & neurobiology. 131(1-2):79-90 [PMID] 12106997.
2002
Chronic cervical spinal sensory denervation reveals ineffective spinal pathways to phrenic motoneurons in the rat.
Neuroscience letters. 323(1):25-8 [PMID] 11911982.
2002
Phrenic long-term facilitation requires spinal serotonin receptor activation and protein synthesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 22(14):6239-46 [PMID] 12122082.
2002
Role of synaptic inhibition in turtle respiratory rhythm generation.
The Journal of physiology. 544(Pt 1):253-65 [PMID] 12356896.

Grants

Jul 2024 ACTIVE
Genetic Determinant of Phrenic Motor Plasticity
Role: Other
Funding: PARKER B FRANCIS FELLOWSHIP FOU
Apr 2023 ACTIVE
Neuroimmune axis contribution to the pathophysiology of pulmonary hypertension
Role: Other
Funding: NATL INST OF HLTH NHLBI
Sep 2022 ACTIVE
Genetic Biomarkers of Intermittent Hypoxia-Induced Respiratory Motor Plasticity in Chronic SCI
Role: Co-Investigator
Funding: US ARMY MED RES ACQUISITION
Aug 2022 ACTIVE
Breathing Research and Therapeutics (BREATHE)
Role: Principal Investigator
Funding: NATL INST OF HLTH NHLBI
Jul 2022 ACTIVE
Chronic hypercapnic hypoxia and respiratory plasticity following cervical spinal injury
Role: Co-Investigator
Funding: CRAIG H NEILSEN FOU
Jan 2022 ACTIVE
Acute adenosine receptor antagonism to promote breathing plasticity in ALS
Role: Principal Investigator
Funding: AMYOTROPHIC LATERAL SCLEROSIS ASSOC
Aug 2021 ACTIVE
Nanoparticle-Based Drug Delivery Targeting the Respiratory Neural Network
Role: Co-Investigator
Funding: NATL INST OF HLTH NINDS
May 2021 – Aug 2022
Projections of opioid-sensitive KF neurons
Role: Other
Funding: NATL INST OF HLTH NIDA
Sep 2020 – Aug 2022
Acute Intermittent Hypoxia to Improve Breathing in Humans with SCI
Role: Other
Funding: CRAIG H NEILSEN FOU
Jan 2020 ACTIVE
Microglial regulation of intermittent hypoxia induced phrenic motor plasticity
Role: Principal Investigator
Funding: NATL INST OF HLTH NHLBI
Jul 2019 ACTIVE
Regulation of Intermittent Hypoxia-Induced Respiratory Motor Plasticity
Role: Principal Investigator
Funding: NATL INST OF HLTH NHLBI
Jul 2019 – Apr 2021
Modulation of Respiratory Motor Plasticity Through Neuron- Microglia Interactions
Role: Other
Funding: PARKER B FRANCIS FELLOWSHIP FOU
Apr 2019 ACTIVE
Optimizing respiratory plasticity with chronic cervical SCI
Role: Principal Investigator
Funding: NATL INST OF HLTH NHLBI
Mar 2019 – Feb 2021
The Two Faces of Hypoxia in Alzheimer's Disease
Role: Principal Investigator
Funding: FL DEPT OF HLTH ED ETHEL MOORE ALZHEIMER
Sep 2018 – Sep 2023
Acute Intermittent Hypoxia and Respiratory Strength Training to Improve Breathing Function after SCI
Role: Co-Project Director/Principal Investigator
Funding: US ARMY MED RES ACQUISITION
Aug 2018 – Jun 2023
Ampakines and Respiratory Neuroplasticity
Role: Co-Investigator
Funding: NATL INST OF HLTH NHLBI
Feb 2018 – Aug 2018
Support for Intermittent Hypoxia Consortium (Conference)
Role: Principal Investigator
Funding: CRAIG H NEILSEN FOU
Nov 2017 – Jun 2022
Chronic intermittent hypoxia-induced neuroinflammation undermines respiratory motor plasticity after chronic incomplete cervical spinal cord injury
Role: Co-Investigator
Funding: US ARMY MED RES AND DEVELOPMENT COMMAND
Jul 2017 – Oct 2021
Combinatorial Therapies to Treat Breathing Impairments After Cervical SCI
Role: Co-Investigator
Funding: CRAIG H NEILSEN FOU
Apr 2017 – Jul 2022
Breathing Research and Therapeutics (BREATHE)
Role: Principal Investigator
Funding: NATL INST OF HLTH NHLBI
Sep 2016 – Jul 2022
Functional mapping of peripheral and central circuits for airway protection and breathing
Role: Co-Investigator
Funding: NATL INST OF HLTH OD
Jun 2016 – May 2019
Mechanisms of intermittent hypoxia-induced motor recovery in persons with SCI
Role: Principal Investigator
Funding: EMORY UNIV via NATL INST OF HLTH
Apr 2016 – Mar 2020
MUSCLE STEM CELLS: NEW ALS GROWTH FACTOR THERAPY AND DISEASEMODEL
Role: Principal Investigator
Funding: *UNIVERSITY OF WISCONSIN MADISON via NATL INST OF HLTH NINDS
Feb 2016 – Nov 2018
Recovery of breathing and forelimb function after prolonged exposure to repetitive acute intermittent hypoxia
Role: Principal Investigator
Funding: US ARMY MED RES ACQUISITION
Oct 2015 – Oct 2016
Therapeutic Intermittent Hypoxia and Functional Recovery of Respiration and Non-respiration Motor Function with Chronic, Incomplete SCI: a "Road Map" to Clinical Translation
Role: Principal Investigator
Funding: CRAIG H NEILSEN FOU
Jul 2015 – Jan 2020
Respiratory Plasticity and Spinal Cord Injury
Role: Principal Investigator
Funding: NATL INST OF HLTH NHLBI
Jan 2015 – Nov 2017
Intermittent Hypoxia-Induced Inflammation Modulates Respiratory Plasticity
Role: Principal Investigator
Funding: *UNIVERSITY OF WISCONSIN MADISON via NATL INST OF HLTH NHLBI
Jul 2006 ACTIVE
BRAIN AND SPINAL CORD INJURY RESEARCH
Role: Project Manager
Funding: FL DEPT OF HLTH

Education

Postdoctoral Fellow
1980-1981 · Department of Preventive Medicine, University of Wisconsin-Madison, Madison, WI, USA
Postdoctoral Fellow
1978-1980 · Max Planck Institute for Experimental Medicine, Goetingen, Germany
PhD in Developmental and Cell Biology
1975-1978 · University of California at Irvine
B.S. in Biological Sciences
1971-1975 · University of California at Irvine

Contact Details

Phones:
Business:
(352) 273-6085
Emails:
Center Coordinator:
Addresses:
Business Mailing:
PO Box 100154
GAINESVILLE FL 32610
Business Street:
1275 CENTER DR
GAINESVILLE FL 32610