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UF Health University of Florida
Center for Advanced Spatial Biomolecule Research Department of Biochemistry & Molecular Biology in the College of Medicine
Research Overview

Publications

2025

2024

2023

[DOI] 10.1016/j.celrep.2023.112196

APOE modulates microglial immunometabolism in response to age, amyloid pathology, and inflammatory challenge

Cell Reports

[DOI] 10.1093/braincomms/fcad091

Cervical spinal cord injury leads to injury and altered metabolism in the lungs

Brain Communications

[DOI] 10.1097/WCO.0000000000001187

Current avenues of gene therapy in Pompe disease

Current Opinion in Neurology

[DOI] 10.1007/s13311-023-01434-9

Gys1 Antisense Therapy Prevents Disease-Driving Aggregates and Epileptiform Discharges in a Lafora Disease Mouse Model

Neurotherapeutics

[DOI] 10.1016/j.crmeth.2023.100455

In situ microwave fixation provides an instantaneous snapshot of the brain metabolome

Cell Reports Methods

[DOI] 10.1038/s41419-023-06202-3

Inhibition of mitochondrial fission activates glycogen synthesis to support cell survival in colon cancer

Nature Cell Death & Disease

[DOI] 10.1016/j.jhep.2023.02.010

Ketohexokinase-C regulates global protein acetylation to decrease carnitine palmitoyltransferase 1a-mediated fatty acid oxidation

Journal of Hepatology

[DOI] 10.1016/j.molmet.2023.101815

Loss of Carnitine Palmitoyltransferase 1a Reduces Docosahexaenoic Acid-Containing Phospholipids and Drives Sexually Dimorphic Liver Disease in Mice

Molecular Metabolism

[DOI] 10.1101/2023.11.27.568931

MetaVision3D: Automated Framework for the Generation of Spatial Metabolome Atlas in 3D

bioRxiv

[DOI] 10.7554/eLife.81717

PASK links cellular energy metabolism with a mitotic self-renewal network to establish differentiation competence

eLife

[DOI] 10.1186/s13023-023-02880-6

Prognostic value of pathogenic variants in Lafora Disease: systematic review and meta-analysis of patient-level data

Orphanet Journal of Rare Diseases

[DOI] 10.1016/j.heliyon.2023.e20384

RIT1 deficiency alters cerebral lipid metabolism and reduces white matter tract oligodendrocytes and conduction velocities

Heliyon

[DOI] 10.1101/2023.07.22.550155

Spatial Metabolome Lipidome and Glycome from a Single brain Section

bioRxiv

[DOI] 10.1038/s41467-023-38437-1

Spatial metabolomics reveals glycogen as an actionable target for pulmonary fibrosis

Nature Communications

[DOI] 10.1101/2023.06.23.546264

Targeting the Microbiome to Improve Gut Health and Breathing Function After Spinal Cord Injury

bioRxiv

2022

[DOI] 10.1038/s41418-022-00974-5

Activation of Drp1 promotes fatty acids-induced metabolic reprograming to potentiate Wnt signaling in colon cancer

Nature Cell Death & Differentiation

[DOI] 10.1016/j.neulet.2021.136428

Analysis of circulating metabolites to differentiate Parkinson’s disease and essential tremor

Neuroscience Letters

[DOI] 10.1165/rcmb.2021-0465OC

ASK1 Regulates Bleomycin-induced Pulmonary Fibrosis

American Journal of Respiratory Cell and Molecular Biology

[DOI] 10.1016/bs.acr.2022.02.005

High-dimensionality reduction clustering of complex carbohydrates to study lung cancer metabolic heterogeneity

Advances in Cancer Research

[DOI] 10.15252/emmm.202216029

In situ mass spectrometry imaging reveals heterogeneous glycogen stores in human normal and cancerous tissues

EMBO Molecular Medicine

[DOI] 10.1002/alz.12523

In situ spatial glycomic imaging of mouse and human Alzheimer's disease brains

Alzheimer's & Dementia

[DOI] 10.1126/scitranslmed.abn2956

Metabolic modulation of synaptic failure and thalamocortical hypersynchronization with preserved consciousness in Glut1 deficiency

Science Translational Medicine

[DOI] 10.1007/978-1-0716-2030-4_15

Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging of Glycogen In Situ

Methods in Molecular Biology

[DOI] 10.21037/tlcr-22-292

NRF2-pathway mutations predict radioresistance in non-small cell lung cancer

Translational Lung Cancer Research

[DOI] 10.1016/j.jbc.2022.102089

The Toxoplasma glucan phosphatase TgLaforin utilizes a distinct functional mechanism that can be exploited by therapeutic inhibitors

Journal of Biological Chemistry

[DOI] 10.3390/ijms23126510

Tissue-Specific Downregulation of Fatty Acid Synthase Suppresses Intestinal Adenoma Formation via Coordinated Reprograming of Transcriptome and Metabolism in the Mouse Model of Apc-Driven Colorectal Cancer

International Journal of Molecular Sciences

[DOI] 10.1007/s13311-022-01240-9

Two Diseases—One Preclinical Treatment Targeting Glycogen Synthesis

Neurotherapeutics

2021

[DOI] 10.1186/s13024-021-00483-y

APOΕ4 lowers energy expenditure in females and impairs glucose oxidation by increasing flux through aerobic glycolysis

Molecular Neurodegeneration

[DOI] 10.1016/j.isci.2021.103276

An empirical pipeline for personalized diagnosis of Lafora disease mutations

iScience

[DOI] 10.1093/brain/awab110

Astrocytic glycogen accumulation drives the pathophysiology of neurodegeneration in Lafora disease

Brain

[DOI] 10.1016/j.cmet.2021.05.003

Brain glycogen serves as a critical glucosamine cache required for protein glycosylation

Cell Metabolism

[DOI] 10.1021/acs.biochem.1c00307

Cooperative Kinetics of the Glucan Phosphatase Starch Excess4

ACS Biochemistry

[DOI] 10.1016/j.tem.2021.09.006

Emerging roles of N-linked glycosylation in brain physiology and disorders

Trends in Endocrinology & Metabolism

[DOI] 10.18632/aging.202849

Enhancing lifespan of budding yeast by pharmacological lowering of amino acid pools

Aging

[DOI] 10.3390/cancers13092157

Evaluation of Glutaminase Expression in Prostate Adenocarcinoma and Correlation with Clinicopathologic Parameters

Cancers

[DOI] 10.1016/j.clinbiochem.2021.03.017

Generation and characterization of a laforin nanobody inhibitor

Clinical Biochemistry

[DOI] 10.1038/s41419-021-04237-y

Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer’s disease

Nature Cell Death & Disease

[DOI] 10.1158/1541-7786.MCR-20-0967

In Situ Analysis of N-Linked Glycans as Potential Biomarkers of Clinical Course in Human Prostate Cancer

Molecular Cancer Research

[DOI] 10.1126/sciadv.abi8602

Lactate supports a metabolic-epigenetic link in macrophage polarization

Science Advances

[DOI] 10.1016/j.jns.2021.117439

Purine synthesis as a target for radiation resistance in molecular glioblastoma

Journal of the Neurological Sciences

[DOI] 10.1097/WCO.0000000000000901

Serotonergic therapy in epilepsy

Current Opinion in Neurology

[DOI] 10.1016/j.xpro.2021.100304

Regional N-glycan and lipid analysis from tissues using MALDI-mass spectrometry imaging

STAR Protocols

[DOI] 10.1080/13816810.2021.1891552

Multimodal imaging and genetic findings in a case of ARSG-related atypical Usher syndrome

Opthalmic Genetics

[DOI] 10.1016/j.yebeh.2021.107975

The 6th International Lafora Epilepsy Workshop: Advances in the search for a cure

Epilepsy & Behavior

2020

[DOI] 10.1016/j.carbpol.2019.115651

Accurate and sensitive quantitation of glucose and glucose phosphates derived from storage carbohydrates by mass spectrometry

Carbohydrate Polymers

[DOI] 10.1016/j.nbd.2020.104742

APOE alters glucose flux through central carbon pathways in astrocytes

Neurobiology of Disease

[DOI] 10.3390/jcm9010138

Clear Cell Adenocarcinoma of the Urinary Bladder Is a Glycogen-Rich Tumor with Poorer Prognosis

Journal of Clinical Medicine

[DOI] 10.1074/jbc.RA119.011081

Improved workflow for mass spectrometry–based metabolomics analysis of the heart

Journal of Biological Chemistry

[DOI] 10.1093/hmg/ddz280

Frontotemporal dementia non-sense mutation of progranulin rescued by aminoglycosides

Human Molecular Genetics

[DOI] 10.3390/cancers12010237

Loss of Rb1 Enhances Glycolytic Metabolism in Kras-Driven Lung Tumors In Vivo

Cancers

[DOI] 10.3390/metabo10120501

Oral Gavage Delivery of Stable Isotope Tracer for In Vivo Metabolomics

Metabolites

[DOI] 10.1194/jlr.ILR120000870

Spatial profiling of gangliosides in mouse brain by mass spectrometry imaging

Journal of Lipid Research

[DOI] 10.1016/j.carbpol.2020.116260

Polyglucosan body structure in Lafora disease

Carbohydrate Polymers

[DOI] 10.1016/j.yebeh.2019.106839

The 5th International Lafora Epilepsy Workshop: Basic science elucidating therapeutic options and preparing for therapies in the clinic

Epilepsy & Behavior

[DOI] 10.21037/atm.2020.01.130

The E3 ligase malin plays a pivotal role in promoting nuclear glycogenolysis and histone acetylation

Annals of Translational Medicine

[DOI] 10.1016/j.bioorg.2020.103856

Design, synthesis, and evaluation of a novel benzamidine-based inhibitor of VEGF-C binding to Neuropilin-2

Bioorganic Chemistry

[DOI] 10.1038/s41589-020-0610-1

Structural dissimilarity from self drives neoepitope escape from immune tolerance

Nature Chemical Biology