2025
[DOI] 10.1038/s42255-025-01242-9
AI-driven framework to map the brain metabolome in three dimensions
Journal: Nature Metabolism
Published: 18 March 2025
[DOI] 10.1038/s41388-025-03297-0
GDP-mannose 4,6-dehydratase is a key driver of MYCN-amplified neuroblastoma core fucosylation and tumorigenesis
Journal: Nature Metabolism
Published: 16 February 2025
[DOI] 10.1038/s42255-025-01243-8
Glycogen drives tumor initiation and progression in lung adenocarcinoma
2024
[DOI] 10.1016/j.eplepsyres.2024.107317
Effect of intracerebroventricular administration of alglucosidase alfa in two mouse models of Lafora disease: Relevance for clinical practice
Epilepsy Research
[DOI] 10.1111/jnc.15906
Glycogen accumulation modulates life span in a mouse model of amyotrophic lateral sclerosis
Journal of Neurochemistry
doi.org/10.1523/JNEUROSCI.1563-23.2024
Imbalance in glucose metabolism regulates the transition of microglia from homeostasis to disease-associated microglia stage 1
The Journal of Neuroscience
https://doi.org/10.1172/jci.insight.184396
Knockdown of ketohexokinase versus inhibition of its kinase activity exert divergent effects on fructose metabolism
PubMed
[DOI] 10.1101/2024.12.10.627800
Neonatal systemic gene therapy restores cardiorespiratory function in a rat model of Pompe disease
bioRxiv
[DOI] 10.1021/acschembio.4c00389
Alteration of Neuropilin-1 and Heparan Sulfate Interaction Impairs Murine B16 Tumor Growth
ACS Chemical Biology
[DOI] 10.1016/j.neurot.2024.e00446
Neurological glycogen storage diseases and emerging therapeutics
Neurotherapeutics
[DOI] 10.3389/fcell.2024.1210944
The crosstalk between neuropilin-1 and tumor necrosis factor-α in endothelial cells
Frontiers in Cell and Developmental Biology
[DOI] 10.1152/jn.00255.2023
Sex and APOE genotype influence respiratory function under hypoxic and hypoxic-hypercapnic conditions
Journal of Neurophysiology
[DOI] 10.1126/scitranslmed.adf1691
Small-molecule inhibition of glycogen synthase 1 for the treatment of Pompe disease and other glycogen storage disorders
Science Translational Medicine
[DOI] 10.1111/jnc.15926
The multifaceted roles of the brain glycogen
Journal of Neurochemistry
[DOI] 10.1038/s41594-023-01166-6
The Ruminococcus bromii amylosome protein Sas6 binds single and double helical α-glucan structures in starch
Nature Structural & Molecular Biology
[DOI] 10.1038/s41386-023-01718-w
Voltage-gated potassium channels control extended access cocaine seeking: a role for nucleus accumbens astrocytes
Neuropsychopharmacology
2023
[DOI] 10.1016/j.celrep.2023.112196
APOE modulates microglial immunometabolism in response to age, amyloid pathology, and inflammatory challenge
Cell Reports
[DOI] 10.1093/braincomms/fcad091
Cervical spinal cord injury leads to injury and altered metabolism in the lungs
Brain Communications
[DOI] 10.1097/WCO.0000000000001187
Current avenues of gene therapy in Pompe disease
Current Opinion in Neurology
[DOI] 10.1007/s13311-023-01434-9
Gys1 Antisense Therapy Prevents Disease-Driving Aggregates and Epileptiform Discharges in a Lafora Disease Mouse Model
Neurotherapeutics
[DOI] 10.1016/j.crmeth.2023.100455
In situ microwave fixation provides an instantaneous snapshot of the brain metabolome
Cell Reports Methods
[DOI] 10.1038/s41419-023-06202-3
Inhibition of mitochondrial fission activates glycogen synthesis to support cell survival in colon cancer
Nature Cell Death & Disease
[DOI] 10.1016/j.jhep.2023.02.010
Ketohexokinase-C regulates global protein acetylation to decrease carnitine palmitoyltransferase 1a-mediated fatty acid oxidation
Journal of Hepatology
[DOI] 10.1016/j.molmet.2023.101815
Loss of Carnitine Palmitoyltransferase 1a Reduces Docosahexaenoic Acid-Containing Phospholipids and Drives Sexually Dimorphic Liver Disease in Mice
Molecular Metabolism
[DOI] 10.1101/2023.11.27.568931
MetaVision3D: Automated Framework for the Generation of Spatial Metabolome Atlas in 3D
bioRxiv
[DOI] 10.7554/eLife.81717
PASK links cellular energy metabolism with a mitotic self-renewal network to establish differentiation competence
eLife
[DOI] 10.1186/s13023-023-02880-6
Prognostic value of pathogenic variants in Lafora Disease: systematic review and meta-analysis of patient-level data
Orphanet Journal of Rare Diseases
[DOI] 10.1016/j.heliyon.2023.e20384
RIT1 deficiency alters cerebral lipid metabolism and reduces white matter tract oligodendrocytes and conduction velocities
Heliyon
[DOI] 10.1101/2023.07.22.550155
Spatial Metabolome Lipidome and Glycome from a Single brain Section
bioRxiv
[DOI] 10.1038/s41467-023-38437-1
Spatial metabolomics reveals glycogen as an actionable target for pulmonary fibrosis
Nature Communications
[DOI] 10.1101/2023.06.23.546264
Targeting the Microbiome to Improve Gut Health and Breathing Function After Spinal Cord Injury
bioRxiv
2022
[DOI] 10.1038/s41418-022-00974-5
Activation of Drp1 promotes fatty acids-induced metabolic reprograming to potentiate Wnt signaling in colon cancer
Nature Cell Death & Differentiation
[DOI] 10.1016/j.neulet.2021.136428
Analysis of circulating metabolites to differentiate Parkinson’s disease and essential tremor
Neuroscience Letters
[DOI] 10.1165/rcmb.2021-0465OC
ASK1 Regulates Bleomycin-induced Pulmonary Fibrosis
American Journal of Respiratory Cell and Molecular Biology
[DOI] 10.1016/bs.acr.2022.02.005
High-dimensionality reduction clustering of complex carbohydrates to study lung cancer metabolic heterogeneity
Advances in Cancer Research
[DOI] 10.15252/emmm.202216029
In situ mass spectrometry imaging reveals heterogeneous glycogen stores in human normal and cancerous tissues
EMBO Molecular Medicine
[DOI] 10.1002/alz.12523
In situ spatial glycomic imaging of mouse and human Alzheimer’s disease brains
Alzheimer’s & Dementia
[DOI] 10.1126/scitranslmed.abn2956
Metabolic modulation of synaptic failure and thalamocortical hypersynchronization with preserved consciousness in Glut1 deficiency
Science Translational Medicine
[DOI] 10.1007/978-1-0716-2030-4_15
Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging of Glycogen In Situ
Methods in Molecular Biology
[DOI] 10.21037/tlcr-22-292
NRF2-pathway mutations predict radioresistance in non-small cell lung cancer
Translational Lung Cancer Research
[DOI] 10.1016/j.jbc.2022.102089
The Toxoplasma glucan phosphatase TgLaforin utilizes a distinct functional mechanism that can be exploited by therapeutic inhibitors
Journal of Biological Chemistry
[DOI] 10.3390/ijms23126510
Tissue-Specific Downregulation of Fatty Acid Synthase Suppresses Intestinal Adenoma Formation via Coordinated Reprograming of Transcriptome and Metabolism in the Mouse Model of Apc-Driven Colorectal Cancer
International Journal of Molecular Sciences
[DOI] 10.1007/s13311-022-01240-9
Two Diseases—One Preclinical Treatment Targeting Glycogen Synthesis
Neurotherapeutics
2021
[DOI] 10.1186/s13024-021-00483-y
APOΕ4 lowers energy expenditure in females and impairs glucose oxidation by increasing flux through aerobic glycolysis
Molecular Neurodegeneration
[DOI] 10.1016/j.isci.2021.103276
An empirical pipeline for personalized diagnosis of Lafora disease mutations
iScience
[DOI] 10.1093/brain/awab110
Astrocytic glycogen accumulation drives the pathophysiology of neurodegeneration in Lafora disease
Brain
[DOI] 10.1016/j.cmet.2021.05.003
Brain glycogen serves as a critical glucosamine cache required for protein glycosylation
Cell Metabolism
[DOI] 10.1021/acs.biochem.1c00307
Cooperative Kinetics of the Glucan Phosphatase Starch Excess4
ACS Biochemistry
[DOI] 10.1016/j.tem.2021.09.006
Emerging roles of N-linked glycosylation in brain physiology and disorders
Trends in Endocrinology & Metabolism
[DOI] 10.18632/aging.202849
Enhancing lifespan of budding yeast by pharmacological lowering of amino acid pools
Aging
[DOI] 10.3390/cancers13092157
Evaluation of Glutaminase Expression in Prostate Adenocarcinoma and Correlation with Clinicopathologic Parameters
Cancers
[DOI] 10.1016/j.clinbiochem.2021.03.017
Generation and characterization of a laforin nanobody inhibitor
Clinical Biochemistry
[DOI] 10.1038/s41419-021-04237-y
Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer’s disease
Nature Cell Death & Disease
[DOI] 10.1158/1541-7786.MCR-20-0967
In Situ Analysis of N-Linked Glycans as Potential Biomarkers of Clinical Course in Human Prostate Cancer
Molecular Cancer Research
[DOI] 10.1126/sciadv.abi8602
Lactate supports a metabolic-epigenetic link in macrophage polarization
Science Advances
[DOI] 10.1016/j.jns.2021.117439
Purine synthesis as a target for radiation resistance in molecular glioblastoma
Journal of the Neurological Sciences
[DOI] 10.1097/WCO.0000000000000901
Serotonergic therapy in epilepsy
Current Opinion in Neurology
[DOI] 10.1016/j.xpro.2021.100304
Regional N-glycan and lipid analysis from tissues using MALDI-mass spectrometry imaging
STAR Protocols
[DOI] 10.1016/j.xpro.2021.100304
Regional N-glycan and lipid analysis from tissues using MALDI-mass spectrometry imaging
STAR Protocols
[DOI] 10.1080/13816810.2021.1891552
Multimodal imaging and genetic findings in a case of ARSG-related atypical Usher syndrome
Opthalmic Genetics
[DOI] 10.1016/j.yebeh.2021.107975
The 6th International Lafora Epilepsy Workshop: Advances in the search for a cure
Epilepsy & Behavior
2020
[DOI] 10.1016/j.carbpol.2019.115651
Accurate and sensitive quantitation of glucose and glucose phosphates derived from storage carbohydrates by mass spectrometry
Carbohydrate Polymers
[DOI] 10.1016/j.nbd.2020.104742
APOE alters glucose flux through central carbon pathways in astrocytes
Neurobiology of Disease
[DOI] 10.3390/jcm9010138
Clear Cell Adenocarcinoma of the Urinary Bladder Is a Glycogen-Rich Tumor with Poorer Prognosis
Journal of Clinical Medicine
[DOI] 10.1074/jbc.RA119.011081
Improved workflow for mass spectrometry–based metabolomics analysis of the heart
Journal of Biological Chemistry
[DOI] 10.1093/hmg/ddz280
Frontotemporal dementia non-sense mutation of progranulin rescued by aminoglycosides
Human Molecular Genetics
[DOI] 10.3390/cancers12010237
Loss of Rb1 Enhances Glycolytic Metabolism in Kras-Driven Lung Tumors In Vivo
Cancers
[DOI] 10.3390/metabo10120501
Oral Gavage Delivery of Stable Isotope Tracer for In Vivo Metabolomics
Metabolites
[DOI] 10.1194/jlr.ILR120000870
Spatial profiling of gangliosides in mouse brain by mass spectrometry imaging
Journal of Lipid Research
[DOI] 10.1016/j.carbpol.2020.116260
Polyglucosan body structure in Lafora disease
Carbohydrate Polymers
[DOI] 10.1016/j.yebeh.2019.106839
The 5th International Lafora Epilepsy Workshop: Basic science elucidating therapeutic options and preparing for therapies in the clinic
Epilepsy & Behavior
[DOI] 10.21037/atm.2020.01.130
The E3 ligase malin plays a pivotal role in promoting nuclear glycogenolysis and histone acetylation
Annals of Translational Medicine
[DOI] 10.1016/j.bioorg.2020.103856
Design, synthesis, and evaluation of a novel benzamidine-based inhibitor of VEGF-C binding to Neuropilin-2
Bioorganic Chemistry
[DOI] 10.1038/s41589-020-0610-1
Structural dissimilarity from self drives neoepitope escape from immune tolerance
Nature Chemical Biology
